Distribution of Lipid-soluble Vitamin Intake among Exclusively Breastfeeding Mothers and its Correlation with Human Milk’s Fatty Acids
DOI:
https://doi.org/10.37134/ejsmt.vol9.2.9.2022Keywords:
Fatty Acids, Human Milk, Lipid-Soluble VitaminAbstract
The lipid composition such as fatty acids and fat-soluble vitamins is the second-most abundant composition of human milk providing dietary energy to infants. Micronutrient dietary intake such as vitamin A, D, E, K and C by breastfeeding mothers plays an important role in regulating the quality of human milk for optimum infant health and growth. The objective of this paper is to determine the distribution and correlation of maternal micronutrient intake of lipid-soluble vitamin and vitamin C towards fatty acids composition in human milk of exclusively breastfeeding mothers. A total of N=36 nursing women were recruited from Dengkil, Selangor, and Kuantan, Pahang, using a convenience sample method. A 24-hour dietary recall (24HR) was performed to collect thorough information on all foods and beverages ingested in the previous 24 hours by the respondent. The data on micronutrients intake per mother was tabulated using Nutritionist Pro. (NP) software. Following the diet recall, the human sample was collected in the next morning and subjected to fatty acid extraction and transesterification using the Blight and Dyer method. The composition of fatty acids methyl esters was analyzed and quantified by a gas chromatography (Agilent 7890A), equipped with a flame ionization detector (FID) and Agilent Chromatography Workstation software. The highest mean of intake occurred during the fifth to sixth months with, 1067.37±629.66 µg RE/day for vitamin A, during the first two months with, 0.89±0.84 µg RE/day of vitamin D, 5.85±2.49 mg/day while during the fifth to sixth months with, 17.28±11.74 µg /day of Vitamin E and at the first two months of lactation period with, 91.60±55.26 mg per day for vitamin C. Despite the fact that there was no significant correlation between vitamin intake and the fatty acid content of human milk, the study discovered a variety of patterns of correlation. Saturated fatty acids (SFA) in human milk were only positively correlated with vitamin D and C, while monounsaturated fatty acids (MUFA) were positively correlated with vitamin A, E, and K and negatively correlated with the rest. As a result, the fatty acid composition of human milk is less dependent on micronutrient dietary intake and more dependent on De-Novo synthesis in the mammary gland.
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References
Lentjes M. (2019). The balance between food and dietary supplements in the general population. The Proceedings of the Nutrition Society, 78(1), 97–109. https://doi.org/10.1017/S0029665118002525
Dror, D. K., & Allen, L. H. (2018). Retinol-to-Fat Ratio and Retinol Concentration in Human Milk Show Similar Time Trends and Associations with Maternal Factors at the Population Level: A Systematic Review and Meta-Analysis. Advances in nutrition (Bethesda, Md.), 9(suppl_1), 332S–346S. https://doi.org/10.1093/advances/nmy021
Oliveira, J. M., Allert, R., & East, C. E. (2016). Vitamin A supplementation for postpartum women. The Cochrane database of systematic reviews, 3, CD005944. https://doi.org/10.1002/14651858.CD005944.pub3
Ballard, O., & Morrow, A. L. (2013). Human milk composition: nutrients and bioactive factors. Pediatric clinics of North America, 60(1), 49–74. https://doi.org/10.1016/j.pcl.2012.10.002
Wagner, C. L., Hulsey, T. C., Fanning, D., Ebeling, M., & Hollis, B. W. (2006). High-dose vitamin D3 supplementation in a cohort of breastfeeding mothers and their infants: a 6-month follow-up pilot study. Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine, 1(2), 59–70. https://doi.org/10.1089/bfm.2006.1.59
de Sousa Rebouças, A., Costa Lemos da Silva, A. G., Freitas de Oliveira, A., Thalia Pereira da Silva, L., de Freitas Felgueiras, V., Cruz, M. S., Silbiger, V. N., da Silva Ribeiro, K. D., & Dimenstein, R. (2019). Factors Associated with Increased Alpha-Tocopherol Content in Milk in Response to Maternal Supplementation with 800 IU of Vitamin E. Nutrients, 11(4), 900. https://doi.org/10.3390/nu11040900
Lima, M. S., Dimenstein, R., & Ribeiro, K. D. (2014). Vitamin E concentration in human milk and associated factors: a literature review. Jornal de pediatria, 90(5), 440–448. https://doi.org/10.1016/j.jped.2014.04.006
Greer F.R. (2001) Are Breast-Fed Infants Vitamin K Deficient?. In: Newburg D.S. (eds) Bioactive Components of Human Milk. Advances in Experimental Medicine and Biology, vol 501. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1371-1_48
Greer FR, Marshall SP, Foley AL, Suttie JW. Improving the vitamin K status of breastfeeding infants with maternal vitamin K supplements. Pediatrics. 1997 Jan;99(1):88-92. doi: 10.1542/peds.99.1.88. PMID: 8989344
Hoppu, U., Rinne, M., Salo-Väänänen, P. et al. Vitamin C in breast milk may reduce the risk of atopy in the infant. Eur J Clin Nutr 59, 123–128 (2005). https://doi.org/10.1038/sj.ejcn.1602048
Ahmed, L, Nazrul Islam, M. N. I. Khan, S. Huque, M. Ahsan, Antioxidant Micronutrient Profile (Vitamin E, C, A, Copper, Zinc, Iron) of Colostrum: Association with Maternal Characteristics, Journal of Tropical Pediatrics, Volume 50, Issue 6, December 2004, Pages 357–358, https://doi.org/10.1093/tropej/50.6.357
Ares Segura, S., Arena Ansótegui, J., Díaz-Gómez, N. M., & en representación del Comité de Lactancia Materna de la Asociación Española de Pediatría (2016). The importance of maternal nutrition during breastfeeding: Do breastfeeding mothers need nutritional supplements?]. Anales de pediatria (Barcelona, Spain : 2003), 84(6), 347.e1–347.e3477. https://doi.org/10.1016/j.anpedi.2015.07.024
Tijerina-Sáenz A, Innis SM, Kitts DD. Antioxidant capacity of human milk and its association with vitamins A and E and fatty acid composition. Acta Paediatr. 2009 Nov;98(11):1793-8. doi: 10.1111/j.1651-2227.2009.01437.x. PMID: 19807706; PMCID: PMC2773529.
Valentine CJ, Morrow G, Fernandez S, Gulati P, Bartholomew D, Long D, Welty SE, Morrow AL, Rogers LK. Docosahexaenoic Acid and Amino Acid Contents in Pasteurized Donor Milk are Low for Preterm Infants. J Pediatr. 2010 Dec;157(6):906-10. doi: 10.1016/j.jpeds.2010.06.017. Epub 2010 Sep 17. PMID: 20850762
Huffman JC, DuBois CM, Mastromauro CA, Moore SV, Suarez L, Park ER. Positive psychological states and health behaviors in acute coronary syndrome patients: A qualitative study. J Health Psychol. 2016;21(6):1026-1036. doi:10.1177/1359105314544135
Newman V. Vitamin A and Breast-Feeding: A Comparison of Data from Developed and Developing Countries. Food and Nutrition Bulletin. 1994;15(2):1-16. doi:10.1177/156482659401500201
Fariza Fadzil, Khadijah Shamsuddin, and Sharifa Ezat Wan Puteh.The Journal of Alternative and Complementary Medicine.Jul 2016.503-508.http://doi.org/10.1089/acm.2013.0469
Ding, Y., Indayati, W., Basnet, T.B. et al. Dietary intake in lactating mothers in China 2018: report of a survey. Nutr J 19, 72 (2020). https://doi.org/10.1186/s12937-020-00589-x
Mohamad, Maznorila & Ling, Chong. (2016). Food taboos of malay pregnant women attending antenatal check-up at the maternal health clinic in Kuala Lumpur. Integrative Food, Nutrition and Metabolism. 3. 10.15761/IFNM.1000140.
Sawal Hamid, Z.B.; Rajikan, R.; Elias, S.M.; Jamil, N.A. Utilization of a Diet Optimization Model in Ensuring Adequate Intake among Pregnant Women in Selangor, Malaysia. Int. J. Environ. Res. Public Health 2019, 16, 4720. https://doi.org/10.3390/ijerph16234720
Som, Vanita & Ashok, Purnima & Kameswari, Sri & Rajendran, Ramaswamy & Singh, Rajpreet. (2016). Comparative antioxidant and bioavailability studies of Vitamin C in Phyllanthus emblica Linn. and its combinations with Piper nigrum Linn. and Zingiber officinale Roscoe. Brazilian Journal of Pharmaceutical Sciences. 52. 35-43. 10.1590/S1984-8250201600010000
C.J. Bates, A.M. Prentice, A. Prentice, A.A. Paul, R.G. Whitehead, Seasonal variations in ascorbic acid status and breast milk ascorbic acid levels in rural Gambian women in relation to dietary intake, Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 76, Issue 3,1982, 341-347, https://doi.org/10.1016/0035-9203(82)90185-7.
Tawfeek HI, Muhyaddin OM, Al-Sanwi HI, Al-Baety N. Effect of Maternal Dietary Vitamin C Intake on the Level of Vitamin C in Breastmilk among Nursing Mothers in Baghdad, Iraq. Food and Nutrition Bulletin. 2002;23(3):244-247. doi:10.1177/156482650202300302
Narchi H, Kochiyil J, Zayed R, Abdulrazzak W, Agarwal M. Maternal vitamin D status throughout and after pregnancy. J Obstet Gynaecol. 2010 Feb;30(2):137-42. doi: 10.3109/01443610903315652. PMID: 20143971
Krešić, G., Dujmović, M., L. Mandić, M. i Redžić, D. (2012). Dietary intake of Croatian lactating women. Croatian journal of food science and technology, 4 (1), 46-53. Preuzeto https://hrcak.srce.hr/84720
Jamil NA, Shahudin NN, Abdul Aziz NS, et al. Knowledge, Attitude and Practice Related to Vitamin D and Its Relationship with Vitamin D Status among Malay Female Office Workers. Int J Environ Res Public Health. 2019;16(23):4735. Published 2019 Nov 27. doi:10.3390/ijerph16234735
Nguyen Bao KL, Sandjaja S, Poh BK, Rojroongwasinkul N, Huu CN, Sumedi E, Aini JN, Senaprom S, Deurenberg P, Bragt M, Khouw I; SEANUTS Study Group. The Consumption of Dairy and Its Association with Nutritional Status in the South East Asian Nutrition Surveys (SEANUTS). Nutrients. 2018 Jun 13;10(6):759. doi: 10.3390/nu10060759. PMID: 29899251; PMCID: PMC6024724.
Leong, YH., Rosma, A., Latiff, A.A. et al. Exposure assessment and risk characterization of aflatoxin B1 in Malaysia. Mycotox Res 27, 207–214 (2011). https://doi.org/10.1007/s12550-011-0097-4
Koletzko B. Human Milk Lipids. Ann Nutr Metab. 2016;69 Suppl 2:28-40. doi: 10.1159/000452819. Epub 2017 Jan 20. PMID: 28103608
Bzikowska-Jura A, Czerwonogrodzka-Senczyna A, Jasińska-Melon E, Mojska H, Olędzka G, A, Szostak-Węgierek D. The Concentration of Omega-3 Fatty Acids in Human Milk Is Related to Their Habitual but Not Current Intake. Nutrients. 2019 Jul 12;11(7):1585. doi: 10.3390/nu11071585. PMID: 31336991; PMCID: PMC6683022.
Butts, C.A.; Hedderley, D.I.; Herath, T.D.; Paturi, G.; Glyn-Jones, S.; Wiens, F.; Stahl, B.; Gopal, P. Human Milk Composition and Dietary Intakes of Breastfeeding Women of Different Ethnicity from the Manawatu-Wanganui Region of New Zealand. Nutrients 2018, 10, 1231. https://doi.org/10.3390/nu10091231
Sinanoglou VJ, Cavouras D, Boutsikou T, Briana DD, Lantzouraki DZ, Paliatsiou S, Volaki P, Bratakos S, Malamitsi-Puchner A, Zoumpoulakis P. Factors affecting human colostrum fatty acid profile: A case study. PLoS One. 2017 Apr 14;12(4):e0175817. doi: 10.1371/journal.pone.0175817. PMID: 28410426; PMCID: PMC5391953.
Antonakou A, Chiou A, Andrikopoulos NK, Bakoula C, Matalas AL. Breast milk tocopherol content during the first six months in exclusively breastfeeding Greek women. Eur J Nutr. 2011 Apr;50(3):195-202. doi: 10.1007/s00394-010-0129-4. Epub 2010 Aug 19. PMID: 20721564.
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Copyright (c) 2022 Malissa Mohamed, Tengku Norbaya Tengku Azhar, Muhammad Rahimi Che Hassan, Umi Shakina Haridan, Noorakmal Abd Wahab, Siti Noorfahana Mohd Idris, Norhafizah Mohd Zazi, Radiah Abdul Ghani
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