Solvent-free Synthesis and Characterization of Cu(II), Co(II) and Ni(II) Complexes of 2-(3-phenylallylidene) thiosemicarbazide

  • Onyinye Chinelo Aguzue Chemistry Advanced Research Center, Sheda Science and Technology Complex, km 10. Abuja-lokoja Road, Sheda Abuja, Nigeria
  • Amowie Philip Oviawe Department of Chemistry, Faculty of Physical Science, University of Benin, Edo State, Nigeria
  • Olutayo Olawumi Olajide Chemistry Advanced Research Center, Sheda Science and Technology Complex, km 10. Abuja-lokoja Road, Sheda Abuja, Nigeria
  • Michael Olalekan Afolayan Chemistry Advanced Research Center, Sheda Science and Technology Complex, km 10. Abuja-lokoja Road, Sheda Abuja, Nigeria
  • Oluwaseye Adedirin Chemistry Advanced Research Center, Sheda Science and Technology Complex, km 10. Abuja-lokoja Road, Sheda Abuja, Nigeria
Keywords: 2-(3-phenylallylidene) thiosemicarbazide, Dimethylsulphoxide, Dimethylformamide, Mechanochemical, Solvent-free

Abstract

Mechanochemical solvent-free synthesis of Cu, Co and Ni complexes of 2-(3-phenylallylidene) thiosemicarbazide is described. The mechanochemical products were characterized on the basis of solubility, melting point, conductivity, FTIR, UV-Visible, GC-MS, 1H-NMR and 13C-NMR. The Schiff base ligand and its metal (II) complexes are coloured stable compounds. The solubility test shows that the compounds are soluble in dimethylsulphoxide, dimethexylformamide; partially soluble in ethanol and insoluble in water. The melting points of the compounds were within the range of 179 oC to 183 oC.  The UV-Visible electronic spectra data showed the different transfers and transitions in the ligand and metal complexes. The different absorptions in the electronic spectra also predicted the possible structures of the complexes. The 13C-NMR and 1H-NMR showed the different carbon and hydrogen environments in the ligand. The GCMS confirmed the structure of the ligand and exhibited different fragments. The antimicrobial activities of the ligand were enhanced with the metal complexes and the results were very interesting as the complexes showed good antifungal and antibacterial activities.

Downloads

Download data is not yet available.

References

Aguzue, O., Oviawe, A.P., Adebiyi, A. (2020). Mechanochemical synthesis and potentiation of the antimicrobial activity of 4-[3-(4-methoxyphenyl) allylideneamino]-1,5-dimethyl-2-phenylpyrazol-3-one by metal chelation. Journal of Science and Mathematics Letters, 8(2), 15-21.

El-Ajaily, M.M., Maihub, A.A., Hudere, S.S., Ben-Saber, S.M. (2006). Nickel (II) Chelate of Schiff base derived from 4-dimethyl-amino-benzaldehyde with cysteine. Asian Journal of Chemical Society, 18 (4), 2427-2430.

Elemike, E.E., Oviawe, A.P., Otuokere I.E. (2011). Potentiation of the antimicrobial activity of 4-benzylimino-2,3-dimethyl-1-phenylpyrazal-5-one by metal chelation. Research Journal of Chemical Sciences, 1(8), 6-11.

Jarrahour, A., Zarei, M. (2008). Solid-solid phase and solvent-free oxidative removal of N-(4-ikoxyphenyl) groups of monocyclic β-lactams with ceric ammonium nitrate as a cheap, simple and efficient method. Synthetic Communications, 38, 1837-1845.

Martins, M.A.P., Frizzo, C.P., Moreira, D.N., Buriol, L., Machado, P. (2009). Solvent-free heterocyclic synthesis. Chemistry Reviews, 109, 4140-4182.

Mikami, K. (2005). Green Reaction Media in Organic Synthesis, Blackwell, Oxford.

Neelakantan, M.A., Esakkiammal, M., Mariappan, S.S., Dharmaraja, J., Jeyakumar, T. (2010). Synthesis, characterization and biocidal activities of some Schiff base metal complexes. Indian Journal of Pharmaceutical Sciences, 72(2), 216-222.

Nwabueze, J.N., Salawu, O.W. (2007). Complexes of Ni(II) and Cu(II) sulphates with hydrazone derived from nicotinic and isonicotinic acids. Journal of Chemical Society of Nigeria, 32(2), 254-259.

Olagboye, S.A., Okoronkwo, A.E., Lajide, L. (2013). Synthesis, characterization and antimicrobial evaluation of mixed ligand complexes of Ni(II) and Co(II) 1,2,3-Triazole with thiocyanate. Research and Reviews: Journal of Chemistry, 2(1), 25-31.

Schmeyers, J., Toda, F., Boy, J., Kaup, G. (1998). Quantitative solid-solid synthesis of azomethines. Journal of the Chemical Society, Perkin Transactions 1, 2, 989-994.

Tanaka, K. (2004). Solvent-free Organic Synthesis, Wiley-VH, Weinheim.

Tanaka, K., Toda, F. (2000). Solvent free Organic synthesis. Chemistry Reviews, 100, 1025-1074.

Published
2021-01-07
How to Cite
Aguzue, O. C., Oviawe, A. P., Olajide, O. O., Afolayan, M. O., & Adedirin, O. (2021). Solvent-free Synthesis and Characterization of Cu(II), Co(II) and Ni(II) Complexes of 2-(3-phenylallylidene) thiosemicarbazide. Journal of Science and Mathematics Letters, 9(1), 11-18. https://doi.org/10.37134/jsml.vol9.1.2.2021