The Effect of Resistance Training on Insulin Sensitivity: A Systematic Review

  • Ahmad Dzulkarnain Ismail Faculty of Sports Science and Recreation, Universiti Teknologi MARA, Perlis Branch, Arau Campus, 02600 Arau, Perlis, MALAYSIA
  • Siti Syahirah Aqilah Shafee Faculty of Sports Science and Recreation, Universiti Teknologi MARA, Perlis Branch, Arau Campus, 02600 Arau, Perlis, MALAYSIA
  • Al Hafiz Abu Bakar Faculty of Sports Science and Recreation, Universiti Teknologi MARA, Perlis Branch, Arau Campus, 02600 Arau, Perlis, MALAYSIA
  • Stuart Gray Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UNITED KINGDOM
  • Harris Kamal Kamaruddin Faculty of Sports Science and Recreation, Universiti Teknologi MARA, Perlis Branch, Arau Campus, 02600 Arau, Perlis, MALAYSIA
  • Ellail Ain Mohd Aznan Faculty of Sports Science and Recreation, Universiti Teknologi MARA, Perlis Branch, Arau Campus, 02600 Arau, Perlis, MALAYSIA
Keywords: insulin resistance, insulin sensitivity, resistance training, strength training


Background: Despite the increasing number of research claiming that resistance training (RT) has an influence on insulin sensitivity, there is still lack of systematic review conducted to determine the degree of evidence. Objective: Therefore, the primary objective of this review was to study the effect of resistance training on insulin sensitivity by examining the available literatures. Methods: A search of all published studies that examined the effect of resistance training on insulin sensitivity were examined using PubMed and Science Direct databases. Specifically, the keywords used were ‘resistance training, strength training, insulin sensitivity, insulin resistance’. During the retrieval process, all articles were rigorously reviewed with exclusion on those that did not fulfill the criteria. Result: Initially, 650 articles were screened and checked for duplication, and 252 articles were retained. The 252 articles were then thoroughly examined through full-text reading. As a result, 23 articles met all the inclusion criteria and were eligible for systematic review. Conclusion: We can conclude that resistance training is an effective way to improve insulin sensitivity.


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Ahmadizad S., Ghorbani S., Ghasemikaram M., & Bahmanzadeh M. (2014). Effects of short- term nonperiodized, linear periodized and daily undulating periodized resistance training on plasma adiponectin, leptin and insulin resistance. Clin Biochem. 2014 Apr;47(6):417-22. doi: 10.1016/j.clinbiochem.2013.12.019.

Alvarez C., Ramirez-Campillo R., Ramirez-Velez R., & Izquierdo M. (2017). Effects and Prevalence of Non-Responders after 12 weeks of High-Intensity Interval or Resistant Training in Adult Woman with Insulin Resistance: A Randomized Trial. Journal of Applied Physiology.

Armstrong, N. (2013). Aerobic fitness and physical activity in children. Pediatric exercise science, 25(4), 548-560.

Benson, A. C., Torode, M. E., & Singh, F. (2008). The effect of high-intensity progressive resistance training on adiposity in children: a randomized controlled trial. International journal of obesity, 32(6), 1016-1027.

Brooks, N., Layne, J. E., Gordon, P. L., Roubenoff, R., Nelson, M. E., & Castaneda-Sceppa,C. (2007). Strength training improves muscle quality and insulin sensitivity in Hispanic older adults with type 2 diabetes. International Journal of Medical Sciences, 4(1), 19– 27.

Burns R. D., Brusseau T. A., & Hannon J. C. (2017). Effect of comprehensive school physical activity programming on cardiometabolic health markers in children from low-income schools. J Phys Act Health. 14(9):671-676.

Burns R.D., Fu Y., & Podlog L.W. (2017). School-based physical activity interventions and physical activity enjoyment: a meta-analysis. Prev Med. 103:84-90.

Burns, R. D., Fu, Y., & Zhang, P. (2019). Resistance Training and Insulin Sensitivity in Youth: A Meta-analysis. American Journal of Health Behavior, 43(2), 228–242.

Colella D., Morano M., Robazza C., & BortolI L. (2009). Body image, perceived physical ability, and motor performance in nonoverweight and overweight Italian children. Percept Mot Skills. 108(1):209-218.

Davis, J. N., Kelly, L. A., Lane, C. J., Ventura, E. E., Byrd-Williams, C. E., Alexandar, K. A., Azen, S. P., Chou, C. P., Spruijt-Metz, D., Weigensberg, M. J., Berhane, K., & Goran,

M. I. (2009). Randomized control trial to improve adiposity and insulin resistance in overweight Latino adolescents. Obesity (Silver Spring, Md.), 17(8), 1542–1548.

Davis, J. N., Tung, A., Chak, S. S., Ventura, E. E., Byrd-Williams, C. E., Alexander, K. E., Lane, C. J., Weigensberg, M. J., Spruijt-Metz, D., & Goran, M. I. (2009). Aerobic and strength training reduces adiposity in overweight Latina adolescents. Medicine and Science in Sports and Exercise, 41(7), 1494–1503.

Faigenbaum A. (2017). Resistance exercise and youth: survival of the strongest. Pediatr Exerc Sci. 29(1):14-18.

Fedewa M.V., Gist N.H., Evans E.M., & Dishman R.K. (2014). Exercise and insulin resistance in youth: a meta-analysis. Pediatrics. 133(1):3163-3174. 10.1542/peds.2013-2718

Hasson, R. E., Adam, T. C., Davis, J. N., Kelly, L. A., Ventura, E. E., Byrd-Williams, C. E.,Toledo-Corral, C. M., Roberts, C. K., Lane, C. J., Azen, S. P., Chou, C. P., Spruijt- Metz, D., Weigensberg, M. J., Berhane, K., & Goran, M. I. (2012). Randomized controlled trial to improve adiposity, inflammation, and insulin resistance in obese African-American and Latino youth. Obesity (Silver Spring, Md.), 20(4), 811–818.

Holten, M. K., Zacho, M., Gaster, M., Juel, C., Wojtaszewski, J. F., & Dela, F. (2004). Strength training increases insulin-mediated glucose uptake, GLUT4 content, and insulin signaling in skeletal muscle in patients with type 2 diabetes. Diabetes, 53(2), 294-305.

Ibañez, J., Izquierdo, M., ARGuelles, I., Forga, L., Larrión, J. L., García-Unciti, M., ... & Gorostiaga, E. M. (2005). Twice-weekly progressive resistance training decreases abdominal fat and improves insulin sensitivity in older men with type 2 diabetes. Diabetes Care, 28(3), 662-667.

Ishii T., Yamakita T., Sato T., Tanaka S., & Fujii S. (1998). Resistance training improves insulin sensitivity in NIDDM subjects without altering maximal oxygen uptake. Diabetes Care. 1998 Aug;21(8):1353-5.

Ismail, A. D., Alkhayl, F. F. A., Wilson, J., Johnston, L., Gill, J. M., & Gray, S. R. (2019). The effect of short‐duration resistance training on insulin sensitivity and muscle adaptations in overweight men. Experimental Physiology, 104(4), 540-545.

Jorge, M. L. M. P., de Oliveira, V. N., Resende, N. M., Paraiso, L. F., Calixto, A., Diniz, A. L. D., & Geloneze, B. (2011). The effects of aerobic, resistance, and combined exercise on metabolic control, inflammatory markers, adipocytokines, and muscle insulin signaling in patients with type 2 diabetes mellitus. Metabolism, 60(9), 1244-1252.

Kumar A. S., Maiya A. G., Shastry B. A., Vaishali K., Ravisha N., Hazari A., Gundmi S., & Jadhav R. (2019). Exercise and insulin resistance in type 2 diabetes mellitus: A systematic review and meta-analysis. Annals of Physical and Rehabilitation Medicine. 62(2): 98-103.

Kelly, L. A., Loza, A., Lin, X., Schroeder, E. T., Hughes, A., Kirk, A., & Knowles, A. M. (2015). The effect of a home-based strength training program on type 2 diabetes risk in obese Latino boys. Journal of Pediatric Endocrinology & Metabolism: JPEM, 28(3-4), 315–322.

Kolahdouzi S., Baghadam M., Kani-Golzar F. A., Saeidi A., Jabbour G., Ayadi A., De Sousa M., Zouita A., Abderrahmane A. B, & Zouhal H. (2019). Progressive circuit resistance training improves inflammatory biomarkers and insulin resistance in obese men. Physiol Behaviour. 2019 Jun 1; 205:15-21.

Lee, J., Kim, D., & Kim, C. (2017). Resistance training for glycemic control, muscular strength, and lean body mass in old type 2 diabetic patients: a meta-analysis. Diabetes Therapy, 8(3), 459-473.

Lee, S., Libman, I., Hughan, K., Kuk, J. L., Jeong, J. H., Zhang, D., & Arslanian, S. (2019). Effects of exercise modality on insulin resistance and ectopic fat in adolescents with overweight and obesity: a randomized clinical trial. The Journal of Pediatrics, 206, 91-98.

Lee, S., Bacha, F., Hannon, T., Kuk, J. L., Boesch, C., & Arslanian, S. (2012). Effects of aerobic versus resistance exercise without caloric restriction on abdominal fat, intrahepatic lipid, and insulin sensitivity in obese adolescent boys: a randomized, controlled trial. Diabetes, 61(11), 2787–2795.

Levy-Marchal C., Arslanian S., Cutfield W., Sinaiko A., Druet C., Marcovecchio M.L., & Chiarelli F. (2010). Insulin resistance in children: consensus, perspective, and future directions. J Clin Endocrinol Metab. 2010;95(12):5189- 5198.

Malin, S. K., Hinnerichs, K. R., Echtenkamp, B. G., Evetovich, T. K., & Engebretsen, B. J. (2013). Effect of adiposity on insulin action after acute and chronic resistance exercise in non-diabetic women. European Journal of Applied Physiology, 113(12), 2933–2941.

Marson, E. C., Delevatti, R. S., Prado, A. K. G., Netto, N., & Kruel, L. F. M. (2016). Effects of aerobic, resistance, and combined exercise training on insulin resistance markers in overweight or obese children and adolescents: A systematic review and meta-analysis. Preventive Medicine, 93, 211-218.

Mavros, Y., Kay, S., Anderberg, K. A., Baker, M. K., Wang, Y., Zhao, R., Meiklejohn, J., Climstein, M., O'Sullivan, A., de Vos, N., Baune, B. T., Blair, S. N., Simar, D., Rooney, K., Singh, N., & Fiatarone Singh, M. A. (2013). Changes in insulin resistance and HbA1c are related to exercise-mediated changes in body composition in older adults with type 2 diabetes: interim outcomes from the GREAT2DO trial. Diabetes Care, 36(8), 2372–2379.

Mayer-Davis E.J., Lawrence J.M., Dabelea D., Divers J., Isom S., Dolan L., Imperatore G., Linder B., Marcovina S., Pettitt D.J., Pihoker C., Saydah S., & Wagenknecht L. (2017). Incidence trends of type 1 and type 2 diabetes among youths, 2002-2012. N Engl J Med. 376(15):1419-1429.

Mogharnasi, M., TaheriChadorneshin, H., Papoli-Baravati, S. A., & Teymuri, A. (2019). Effects of upper-body resistance exercise training on serum nesfatin-1 level, insulin resistance, and body composition in obese paraplegic men. Disability and Health Journal, 12(1), 29-34.

Mogharnasi M., TajiTabas A., Tashakorizadeh M., & Nayebifar S. H. (2018). The Effects of Resistance and Endurance Training on Levels of Nesfatin-1, HSP70, Insulin Resistance and Body Composition in Women with Type 2 Diabetes Mellitus. Science & Sports

Nery, C., Moraes, S., Novaes, K. A., Bezerra, M. A., Silveira, P., & Lemos, A. (2017). Effectiveness of resistance exercise compared to aerobic exercise without insulin therapy in patients with type 2 diabetes mellitus: a meta-analysis. Brazilian Journal of Physical Therapy, 21(6), 400–415.

Poehlman E. T., Dvorak R. V., DeNino W. F., Brochu M., & Ades P. A. (2000). Effects of resistance training and endurance training on insulin sensitivity in nonobese, young women: a controlled randomized trial. J Clin Endocrinol Metab. 2000 Jul;85(7):2463- 8.

Schmitz, K. H., Ahmed, R. L., Hannan, P. J., & Yee, D. (2005). Safety and efficacy of weight training in recent breast cancer survivors to alter body composition, insulin, and insulin-like growth factor axis proteins. Cancer Epidemiology Biomarkers & Prevention, 14(7), 1672-1680.

Shaibi G. Q., Cruz M. L., Ball G. D., Weigensberg M. J., Salem G. J., Crespo N. C., & Goran M. I. (2006). Effects of resistance training on insulin sensitivity in overweight Latino adolescent males. Med Sci Sports Exerc. 2006 Jul;38(7):1208-15.

Shamseer, L., Moher, D., Clarke, M., Ghersi, D., Liberati, A., Petticrew, M., ... & Stewart, L. A. (2015). Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015: elaboration and explanation. Bmj, 349. 10.1136/bmj. g7647.

Slentz, C. A., Bateman, L. A., Willis, L. H., Shields, A. T., Tanner, C. J., Piner, L. W., Hawk, V. H., Muehlbauer, M. J., Samsa, G. P., Nelson, R. C., Huffman, K. M., Bales, C. W., Houmard, J. A., & Kraus, W. E. (2011). Effects of aerobic vs. resistance training on visceral and liver fat stores, liver enzymes, and insulin resistance by HOMA in overweight adults from STRRIDE AT/RT. American Journal of Physiology. Endocrinology and Metabolism, 301(5), E1033–E1039.

Suh, S., Jeong, I. K., Kim, M. Y., Kim, Y. S., Shin, S., Kim, S. S., & Kim, J. H. (2011). Effects of resistance training and aerobic exercise on insulin sensitivity in overweight korean adolescents: a controlled randomized trial. Diabetes & Metabolism Journal, 35(4), 418–426.

Williams, M. A., Haskell, W. L., Ades, P. A., Amsterdam, E. A., Bittner, V., Franklin, B. A., ... & Stewart, K. J. (2007). Resistance exercise in individuals with and without cardiovascular disease: 2007 update: a scientific statement from the American Heart Association Council on Clinical Cardiology and Council on Nutrition, Physical Activity, and Metabolism. Circulation, 116(5), 572-584.

How to Cite
Ismail, A. D., Shafee, S. S. A., Abu Bakar, A. H., Gray, S., Kamaruddin, H. K., & Mohd Aznan, E. A. (2022). The Effect of Resistance Training on Insulin Sensitivity: A Systematic Review. Jurnal Sains Sukan & Pendidikan Jasmani, 11(2), 1-16.