A Review on Recent Trends of 3D Printing Technology and Its Approaches in Current Drug Delivery
DOI:
https://doi.org/10.37134/jsml.vol13.1.8.2025Keywords:
3D printing technology, Inkjet printing, Extrusion-based printing, Powder-based binding method, Laser based 3D printingAbstract
Three-dimensional printing (3DP) is emerging as a groundbreaking technology in the pharmaceutical industry, promising transformative advancements in drug formulation and delivery. This innovative method enables the creation of personalized medications with precise dosages and tailored release profiles, addressing the limitations of traditional mass production. Despite its promising potential, the widespread adoption of 3DP in medicine faces several challenges. The primary issue is the lack of comprehensive regulatory guidelines, which creates uncertainty regarding standardization and quality control. Ensuring the quality and stability of 3D-printed drugs is another critical concern, with non-destructive evaluation methods like Near-Infrared and Raman spectroscopy being explored for real-time quality assessment. Additionally, current 3D printers often do not fully comply with Good Manufacturing Practice standards, which are essential for ensuring product consistency and safety. This study provides a comprehensive examination of recent trends and innovative approaches in 3DP technology applied to drug delivery systems, highlighting both the progress made and the challenges that need to be addressed. By examining current methodologies, materials, and applications, the research aims to elucidate the evolving landscape of 3D-printed pharmaceuticals. The study focuses on evaluating the feasibility, efficacy, and scalability of diverse 3DP approaches in developing personalized and precision drug formulations. These insights are intended to enhance the field of pharmaceutical sciences and support patient-centric healthcare by offering more customized and effective medication solutions. Through a comprehensive analysis of innovative 3DP techniques, the research seeks to contribute to the advancement of drug delivery systems, potentially revolutionizing the way medications are produced and administered.
References
Abdelgader A, Govender M, Kumar P, Choonara YE. (2024). A novel intrauterine device for the spatio-temporal release of norethindrone acetate as a counter-estrogenic intervention in the genitourinary syndrome of menopause. Pharmaceutics, 16(5), 587.
Acosta-Vélez GF, Linsley CS, Craig MC, Wu BM. (2017). Photocurable bioink for the inkjet 3D pharming of hydrophilic drugs. Bioengineering, 4(1), 11.
Acosta-Vélez GF, Zhu TZ, Linsley CS, Wu BM. (2018). Photocurable poly (ethylene glycol) as a bioink for the inkjet 3D pharming of hydrophobic drugs. International Journal of Pharmaceutics, 546(1-2), 145-153.
Al-Dulimi Z, Wallis M, Tan DK, Maniruzzaman M, Nokhodchi A. (2021). 3D printing technology as innovative solutions for biomedical applications. Drug Discovery Today, 26(2), 360-383.
Alhijjaj M, Belton P, Qi S. (2016). An investigation into the use of polymer blends to improve the printability of and regulate drug release from pharmaceutical solid dispersions prepared via fused deposition modeling (FDM) 3D printing. European Journal of Pharmaceutics and Biopharmaceutics, 108, 111-125.
Allen EA, O’Mahony C, Cronin M, O’Mahony T, Moore AC, Crean AM. (2016). Dissolvable microneedle fabrication using piezoelectric dispensing technology. International Journal of Pharmaceutics, 500(1-2), 1-10.
Arora L, Chakraborty T. (2017). A review on new generation orodispersible films and its novel approaches. Indo American Journal of Pharmaceutical Research, 7, 7451-7470.
Auriemma G, Tommasino C, Falcone G, Esposito T, Sardo C, Aquino RP. (2022). Additive manufacturing strategies for personalized drug delivery systems and medical devices: fused filament fabrication and semi solid extrusion. Molecules, 27(9), 2784.
Auvinen VV, Virtanen J, Merivaara A, Virtanen V, Laurén P, Tuukkanen S, Laaksonen T. (2020). Modulating sustained drug release from nanocellulose hydrogel by adjusting the inner geometry of implantable capsules. Journal of Drug Delivery Science and Technology, 57, 101625.
Awad A, Fina F, Goyanes A, Gaisford S, Basit AW. (2020). 3D printing: Principles and pharmaceutical applications of selective laser sintering. International Journal of Pharmaceutics, 586, 119594.
Bácskay I, Ujhelyi Z, Fehér P, Arany P. (2022). The evolution of the 3D-printed drug delivery systems: a review. Pharmaceutics, 14(7), 1312.
Bao Q, Zou Y, Wang Y, Kozak D, Choi S, Burgess DJ. (2019). Drug release testing of long-acting intrauterine systems. Journal of Controlled Release, 316, 349-358.
Beck RC, Chaves PS, Goyanes A, Vukosavljevic B, Buanz A, Windbergs M, Basit AW, Gaisford S. (2017). 3D printed tablets loaded with polymeric nanocapsules: An innovative approach to produce customized drug delivery systems. International Journal of Pharmaceutics, 528(1-2), 268-279.
Beg S, Almalki WH, Malik A, Farhan M, Aatif M, Rahman Z, Alruwaili NK, Alrobaian M, Tarique M, Rahman M. (2020). 3D printing for drug delivery and biomedical applications. Drug Discovery Today, 25(9), 1668-1681.
Bharadwaj VT. (2019). New record of mangrove lichens from Andhra Pradesh and Orissa states of India. Studies in Fungi, 4(1), 97-100.
Bhattacharya S, Singh SK, Shrestha S, Baghel YS, Maity D, Kumar A, Gupta GD, Kumar R. (2019). Recent findings and development of 3D printing technology in pharmaceutical formulation development: an extensive review. International Journal of Drug Development and Research, 11, 1-14.
Biedermann T, Boettcher-Haberzeth S, Reichmann E. (2013). Tissue engineering of skin for wound coverage. European Journal of Pediatric Surgery, 23(05), 375-382.
Boehm RD, Miller PR, Daniels J, Stafslien S, Narayan RJ. (2014). Inkjet printing for pharmaceutical applications. Materials Today, 17(5), 247-252.
Boehm RD, Miller PR, Schell WA, Perfect JR, Narayan RJ. (2013). Inkjet printing of amphotericin B onto biodegradable microneedles using piezoelectric inkjet printing. Jom, 65, 525-533.
Bozkurt Y, Karayel E. (2021). 3D printing technology; methods, biomedical applications, future opportunities and trends. Journal of Materials Research and Technology, 14, 1430-1450.
Buanz AB, Saunders MH, Basit AW, Gaisford S. (2011). Preparation of personalized-dose salbutamol sulphate oral films with thermal ink-jet printing. Pharmaceutical Research, 28, 2386-2392.
Carou‐Senra P, Rodríguez‐Pombo L, Awad A, Basit AW, Alvarez‐Lorenzo C, Goyanes A. (2024). Inkjet printing of pharmaceuticals. Advanced Materials, 36(11), 2309164.
Castrejon-Pita JR, Baxter WR, Morgan J, Temple S, Martin GD, Hutchings IM. (2013). Future, opportunities and challenges of inkjet technologies. Atomization and Sprays, 23(6), 541-565.
Chai X, Chai H, Wang X, Yang J, Li J, Zhao Y, Cai W, Tao T, Xiang X. (2017). Fused deposition modeling (FDM) 3D printed tablets for intragastric floating delivery of domperidone. Scientific Reports, 7(1), 2829.
Charoo NA, Barakh Ali SF, Mohamed EM, Kuttolamadom MA, Ozkan T, Khan MA, Rahman Z. (2020). Selective laser sintering 3D printing–an overview of the technology and pharmaceutical applications. Drug Development and Industrial Pharmacy, 46(6), 869-877.
Chaudhari VS, Malakar TK, Murty US, Banerjee S. (2021). Extruded filaments derived 3D printed medicated skin patch to mitigate destructive pulmonary tuberculosis: Design to delivery. Expert Opinion on Drug Delivery, 18(2), 301-313.
Chouhan D, Dey N, Bhardwaj N, Mandal BB. (2019). Emerging and innovative approaches for wound healing and skin regeneration: Current status and advances. Biomaterials, 216, 119267.
Chu W, Tan Y, Wang P, Xu J, Li W, Qi J, Cheng Y. (2018). Centimeter‐height 3D printing with femtosecond laser two‐photon polymerization. Advanced Materials Technologies, 3(5), 1700396.
Conceição J, Farto-Vaamonde X, Goyanes A, Adeoye O, Concheiro A, CabralMarques H, Lobo JM, Alvarez-Lorenzo C. (2019). Hydroxypropyl-β-cyclodextrin-based fast dissolving carbamazepine printlets prepared by semisolid extrusion 3D printing. Carbohydrate Polymers, 221, 55-62.
Couți N, Porfire A, Iovanov R, Crișan AG, Iurian S, Casian T, Tomuță I. (2024). Polyvinyl Alcohol, a versatile excipient for pharmaceutical 3D printing. Polymers, 16(4), 517.
Cubo N, Garcia M, Del Cañizo JF, Velasco D, Jorcano JL. (2016). 3D bioprinting of functional human skin: production and in vivo analysis. Biofabrication, 9(1), 015006.
Cui M, Pan H, Fang D, Qiao S, Wang S, Pan W. (2020). Fabrication of high drug loading levetiracetam tablets using semi-solid extrusion 3D printing. Journal of Drug Delivery Science and Technology, 57, 101683.
Daikuara LY, Chen X, Yue Z, Skropeta D, Wood FM, Fear MW, Wallace GG. (2022). 3D bioprinting constructs to facilitate skin regeneration. Advanced Functional Materials, 32(3), 2105080.
Daly R, Harrington TS, Martin GD, Hutchings IM. (2015). Inkjet printing for pharmaceutics–a review of research and manufacturing. International Journal of Pharmaceutics, 494(2), 554-567.
de Oliveira TV, de Oliveira RS, Dos Santos J, Funk NL, Petzhold CL, Beck RC. (2022). Redispersible 3D printed nanomedicines: An original application of the semisolid extrusion technique. International Journal of Pharmaceutics, 624, 122029.
Desu PK, Maddiboyina B, Vanitha K, Rao Gudhanti SN, Anusha R, Jhawat V. (2021). 3D printing technology in pharmaceutical dosage forms: advantages and challenges. Current Drug Targets, 22(16), 1901-1914.
Dine A, Bentley E, PoulmarcK LA, Dini D, Forte AE, Tan Z. (2021). A dual nozzle 3D printing system for super soft composite hydrogels. HardwareX, 9, e00176.
Dumpa N, Butreddy A, Wang H, Komanduri N, Bandari S, Repka MA. (2021). 3D printing in personalized drug delivery: An overview of hot-melt extrusion-based fused deposition modeling. International Journal of Pharmaceutics, 600, 120501.
Economidou SN, Lamprou DA, Douroumis D. (2018). 3D printing applications for transdermal drug delivery. International Journal of Pharmaceutics, 544(2), 415-424.
Economidou SN, Pere CP, Reid A, Uddin MJ, Windmill JF, Lamprou DA, Douroumis D. (2019). 3D printed microneedle patches using stereolithography (SLA) for intradermal insulin delivery. Materials Science and Engineering: C, 102, 743-755.
Ehtezazi T, Algellay M, Islam Y, Roberts M, Dempster NM, Sarker SD. (2018). The application of 3D printing in the formulation of multilayered fast dissolving oral films. Journal of Pharmaceutical Sciences, 107(4), 1076-1085.
Fanse S, Bao Q, Burgess DJ. (2022). Long-acting intrauterine systems: Recent advances, current challenges, and future opportunities. Advanced Drug Delivery Reviews, 191, 114581.
Farias C, Lyman R, Hemingway C, Chau H, Mahacek A, Bouzos E, Mobed-Miremadi M. (2018). Three-dimensional (3D) printed microneedles for microencapsulated cell extrusion. Bioengineering, 5(3), 59.
Fu J, Yu X, Jin Y. (2018). 3D printing of vaginal rings with personalized shapes for controlled release of progesterone. International Journal of Pharmaceutics, 539(1-2), 75-82.
Gbureck U, Vorndran E, Müller FA, Barralet JE. (2007). Low temperature direct 3D printed bioceramics and biocomposites as drug release matrices. Journal of Controlled Release, 122(2), 173-180.
Ge Q, Li Z, Wang Z, Kowsari K, Zhang W, He X, Zhou J, Fang NX. (2020). Projection micro stereolithography based 3D printing and its applications. International Journal of Extreme Manufacturing, 2(2), 022004.
Genina N, Fors D, Vakili H, Ihalainen P, Pohjala L, Ehlers H, Kassamakov I, Haeggström E, Vuorela P, Peltonen J, Sandler N. (2012). Tailoring controlled-release oral dosage forms by combining inkjet and flexographic printing techniques. European Journal of Pharmaceutical Sciences, 47(3), 615-623.
Genina N, Holländer J, Jukarainen H, Mäkilä E, Salonen J, Sandler N. (2016). Ethylene vinyl acetate (EVA) as a new drug carrier for 3D printed medical drug delivery devices. European Journal of Pharmaceutical Sciences, 90, 53-63.
Genina N, Janßen EM, Breitenbach A, Breitkreutz J, Sandler N. (2013). Evaluation of different substrates for inkjet printing of rasagiline mesylate. European Journal of Pharmaceutics and Biopharmaceutics, 85(3), 1075-1083.
Germini G, Peltonen L. (2021). 3D printing of drug nanocrystals for film formulations. Molecules, 26(13), 3941.
Ghidini T. (2018). Regenerative medicine and 3D bioprinting for human space exploration and planet colonisation. Journal of Thoracic Disease, 10(Suppl 20), S2363.
Gioumouxouzis CI, Tzimtzimis E, Katsamenis OL, Dourou A, Markopoulou C, Bouropoulos N, Tzetzis D, Fatouros DG. (2020). Fabrication of an osmotic 3D printed solid dosage form for controlled release of active pharmaceutical ingredients. European Journal of Pharmaceutical Sciences, 143, 105176.
Goyanes A, Allahham N, Trenfield SJ, Stoyanov E, Gaisford S, Basit AW. (2019). Direct powder extrusion 3D printing: Fabrication of drug products using a novel singlestep process. International Journal of Pharmaceutics, 567, 11847.
Goyanes A, Buanz AB, Basit AW, Gaisford S. (2014). Fused-filament 3D printing (3DP) for fabrication of tablets. International Journal of Pharmaceutics, 476(1-2), 88-92.
Goyanes A, Buanz AB, Hatton GB, Gaisford S, Basit AW. (2015). 3D printing of modified-release aminosalicylate (4-ASA and 5-ASA) tablets. European Journal of Pharmaceutics and Biopharmaceutics, 89, 157-162.
Goyanes A, Det-Amornrat U, Wang J, Basit AW, Gaisford S. (2016). 3D scanning and 3D printing as innovative technologies for fabricating personalized topical drug delivery systems. Journal of Controlled Release, 234, 41-48.
Goyanes A, Kobayashi M, Martínez-Pacheco R, Gaisford S, Basit AW. (2016). Fused-filament 3D printing of drug products: Microstructure analysis and drug release characteristics of PVA-based caplets. International Journal of Pharmaceutics, 514(1), 290-295.
Gu Y, Chen X, Lee JH, Monteiro DA, Wang H, Lee WY. (2012). Inkjet printed antibioticand calcium-eluting bioresorbablenanocompositemicropatterns for orthopedic implants. Actabiomaterialia, 8(1), 424-431.
Gungor-Ozkerim PS, Inci I, Zhang YS, Khademhosseini A, Dokmeci MR. (2018). Bioinks for 3D bioprinting: an overview. Biomaterials Science, 6(5), 915-946.
Gurunath S, Kumar SP, Basavaraj NK, Patil PA. (2013). Amorphous solid dispersion method for improving oral bioavailability of poorly water-soluble drugs. Journal of Pharmacy Research, 6(4), 476-480.
Haritha P, Patnaik SK, Tatipamula VB. (2019). Chemical and pharmacological evaluation of Manglicolous lichen Graphis ajarekarii PATW. & CR KULK. Vietnam Journal of Science and Technology, 57(3), 300-308.
Hatami H, Mojahedian MM, Kesharwani P, Sahebkar A. (2024). Advancing personalized medicine with 3D printed combination drug therapies: A comprehensive review of application in various conditions. European Polymer Journal, 113245.
Hauptstein S, Prüfert F, Bernkop-Schnürch A. (2015). Self-nanoemulsifying drug delivery systems as novel approach for pDNA drug delivery. International Journal of Pharmaceutics, 487(1-2), 25-31.
Helú MA, Liu L. (2021). Fused deposition modeling (FDM) based 3D printing of microelectrodes and multi-electrode probes. Electrochimica Acta, 365, 137279.
Ho CMB, Ng SH, Yoon YJ. (2015). A review on 3D printed bioimplants. International Journal of Precision Engineering and Manufacturing, 16, 1035-1046.
Holländer J, Genina N, Jukarainen H, Khajeheian M, Rosling A, Mäkilä E, Sandler N. (2016). Three-dimensional printed PCL-based implantable prototypes of medical devices for controlled drug delivery. Journal of Pharmaceutical Sciences, 105(9), 2665-2676.
Holländer J, Hakala R, Suominen J, Moritz N, Yliruusi J, Sandler N. (2018). 3D printed UV light cured polydimethylsiloxane devices for drug delivery. International Journal of Pharmaceutics, 544(2), 433-442.
Huang J, Qin Q, Wang J. (2020). A review of stereolithography: Processes and systems. Processes, 8(9), 1138.
Ibrahim M, Maslehuddin M. (2021). An overview of factors influencing the properties of alkali-activated binders. Journal of Cleaner Production, 286, 124972.
Izdebska-Podsiadły J. (2022). Classification of 3D printing methods. In Polymers for 3D printing. William Andrew Publishing, Poland. p. 23-34.
Jain K, Shukla R, Yadav A, Ujjwal RR, Flora SJ. (2021). 3D printing in development of nanomedicines. Nanomaterials, 11(2), 420.
Jakus AE. (2019). An introduction to 3D printing – past, present, and future promise. In 3D Printing in Orthopaedic Surgery. Edited by Matthew Dipaola and Felasfa M. Wodajo, Elsevier, United States. p. 1-15. doi:10.1016/B978-0-323-58118-9.00001-4
Jamróz W, Kurek M, Łyszczarz E, Szafraniec J, Knapik-Kowalczuk J, Syrek K, Paluch M, Jachowicz R. (2017). 3D printed orodispersible films with Aripiprazole. International Journal of Pharmaceutics, 533(2), 413-420.
Jamróz W, Szafraniec J, Kurek M, Jachowicz R. (2018). 3D printing in pharmaceutical and medical applications–recent achievements and challenges. Pharmaceutical Research, 35, 1-22.
Jandyal A, Chaturvedi I, Wazir I, Raina A, Haq MI. (2022). 3D printing–A review of processes, materials and applications in industry 4.0. Sustainable Operations and Computers, 3, 33-42.
Kafle A, Luis E, Silwal R, Pan HM, Shrestha PL, Bastola AK. (2021). 3D/4D printing of polymers: fused deposition modelling (FDM), selective laser sintering (SLS), and stereolithography (SLA). Polymers, 13(18), 3101.
Kalhori D, Zakeri N, Zafar-Jafarzadeh M, Moroni L, Solati-Hashjin M. (2022). Cardiovascular 3D bioprinting: A review on cardiac tissue development. Bioprinting, 28, e00221.
Kalyan BGP, Mehrotra S, Marques SM, Kumar L, Verma R. (2023). 3D printing in personalized medicines: A focus on applications of the technology. Materials Today Communications, 35,105875.
Katstra WE, Palazzolo RD, Rowe CW, Giritlioglu B, Teung P, Cima MJ. (2000). Oral dosage forms fabricated by Three Dimensional Printing™. Journal of Controlled Release, 66(1), 1-9.
Kazi M, Al-Swairi M, Ahmad A, Raish M, Alanazi FK, Badran MM, Khan AA, Alanazi AM, Hussain MD. (2019). Evaluation of self-nanoemulsifying drug delivery systems (SNEDDS) for poorly water-soluble talinolol: Preparation, in vitro and in vivo assessment. Frontiers in Pharmacology, 10, 459.
Kean EA, Adeleke OA. (2023). Orally disintegrating drug carriers for paediatric pharmacotherapy. European Journal of Pharmaceutical Sciences, 182, 106377.
Kempin W, Franz C, Koster LC, Schneider F, Bogdahn M, Weitschies W, Seidlitz A. (2017). Assessment of different polymers and drug loads for fused deposition modeling of drug loaded implants. European Journal of Pharmaceutics and Biopharmaceutics, 115, 84-93.
Kérourédan O, Ribot EJ, Fricain JC, Devillard R, Miraux S. (2018). Magnetic Resonance Imaging for tracking cellular patterns obtained by Laser-Assisted Bioprinting. Scientific Reports, 8(1), 15777.
Khaled SA, Burley JC, Alexander MR, Yang J, Roberts CJ. (2015). 3D printing of tablets containing multiple drugs with defined release profiles. International Journal of Pharmaceutics, 494(2), 643-650.
Khoo ZX, Liu Y, An J, Chua CK, Shen YF, Kuo CN. (2018). A review of selective laser melted NiTi shape memory alloy. Materials, 11(4), 519.
Klein S, Tietz K. (2019). Vaginal and intrauterine delivery systems. In Vitro Drug Release Testing of Special Dosage Forms, 177-209.
Kruth JP, Mercelis P, Van Vaerenbergh J, Froyen L, Rombouts M. (2005). Binding mechanisms in selective laser sintering and selective laser melting. Rapid Prototyping Journal, 11(1), 26-36.
Kruth JP, Wang X, Laoui T, Froyen L. (2003). Lasers and materials in selective laser sintering. Assembly Automation, 23(4), 357-371.
Lee BK, Yun YH, Choi JS, Choi YC, Kim JD, Cho YW. (2012). Fabrication of drugloaded polymer microparticles with arbitrary geometries using a piezoelectric inkjet printing system. International Journal of Pharmaceutics, 427(2), 305-310.
Lee KJ, Kang A, Delfino JJ, West TG, Chetty D, Monkhouse DC, Yoo J. (2003). Evaluation of critical formulation factors in the development of a rapidly dispersing captopril oral dosage form. Drug Development and Industrial Pharmacy, 29(9), 967-979.
Li N, Khan SB, Chen S, Aiyiti W, Zhou J, Lu B. (2023). Promising new horizons in medicine: Medical advancements with nanocomposite manufacturing via 3D printing. Polymers, 15(20), 4122.
Li Q, Guan X, Cui M, Zhu Z, Chen K, Wen H, Jia D, Hou J, Xu W, Yang X, Pan W. (2018). Preparation and investigation of novel gastro-floating tablets with 3D extrusion-based printing. International Journal of Pharmaceutics, 535(1- 2), 325-332.
Liaw CY, Guvendiren M. (2017). Current and emerging applications of 3D printing in medicine. Biofabrication, 9(2), 024102.
Lim SH, Kathuria H, Tan JJ, Kang L. (2018). 3D printed drug delivery and testing systems – a passing fad or the future. Advanced Drug Delivery Reviews, 132, 139-168.
Lim SH, Ng JY, Kang L. (2017). Three-dimensional printing of a microneedle array on personalized curved surfaces for dual-pronged treatment of trigger finger. Biofabrication, 9(1), 015010.
Lu Y, Mantha SN, Crowder DC, Chinchilla S, Shah KN, Yun YH, Wicker RB, Choi JW. (2015). Microstereolithography and characterization of poly (propylene fumarate)-based drug-loaded microneedle arrays. Biofabrication, 7(4), 045001.
Luzuriaga MA, Berry DR, Reagan JC, Smaldone RA, Gassensmith JJ. (2018). Biodegradable 3D printed polymer microneedles for transdermal drug delivery. Lab on a Chip, 18(8), 1223-1230.
Ma X, Yu C, Wang P, Xu W, Wan X, Lai CS, Liu J, Koroleva-Maharajh A, Chen S. (2018). Rapid 3D bioprinting of decellularized extracellular matrix with regionally varied mechanical properties and biomimetic microarchitecture. Biomaterials, 185, 310-321.
Madla CM, Trenfield SJ, Goyanes A, Gaisford S, Basit AW. (2018). 3D printing technologies, implementation and regulation: An overview. 3D Printing of Pharmaceuticals, 21-40.
Maroni A, Melocchi A, Parietti F, Foppoli A, Zema L, Gazzaniga A. (2017). 3D printed multi-compartment capsular devices for two-pulse oral drug delivery. Journal of Controlled Release, 268, 10-18.
Melocchi A, Parietti F, Loreti G, Maroni A, Gazzaniga A, Zema L. (2015). 3D printing by fused deposition modeling (FDM) of a swellable/erodible capsular device for oral pulsatile release of drugs. Journal of Drug Delivery Science and Technology, 30, 360-367.
Melocchi A, Parietti F, Maroni A, Foppoli A, Gazzaniga A, Zema L. (2016). Hot-melt extruded filaments based on pharmaceutical grade polymers for 3D printing by fused deposition modeling. International Journal of Pharmaceutics, 509(1- 2), 255-263.
Mohammed AA, Algahtani MS, Ahmad MZ, Ahmad J, Kotta S. (2021). 3D Printing in medicine: Technology overview and drug delivery applications. Annals of 3D Printed Medicine, 4, 100037.
Mohapatra S, Kar RK, Biswal PK, Bindhani S. (2022). Approaches of 3D printing in current drug delivery. Sensors International, 3, 100146.
Muhindo D, Elkanayati R, Srinivasan P, Repka MA, Ashour EA. (2023). Recent advances in the applications of additive manufacturing (3D printing) in drug delivery: a comprehensive review. AAPS PharmSciTech. 24(2), 57.
Muwaffak Z, Goyanes A, Clark V, Basit AW, Hilton ST, Gaisford S. (2017). Patient-specific 3D scanned and 3D printed antimicrobial polycaprolactone wound dressings. International Journal of Pharmaceutics, 527(1-2), 161-170.
Nagarajan N, Dupret-Bories A, Karabulut E, Zorlutuna P, Vrana NE. (2018). Enabling personalized implant and controllable biosystem development through 3D printing. Biotechnology Advances, 36(2), 521-533.
Ngo TD, Kashani A, Imbalzano G, Nguyen KT, Hui D. (2018). Additive manufacturing (3D printing): A review of materials, methods, applications and challenges. Composites Part B: Engineering, 143, 172-196.
Nguyen HT, Polimati H, Annam SS, Okello E, Thai QM, Vu TY, Tatipamula VB. (2022). Lobaric acid prevents the adverse effects of tetramethrin on the estrous cycle of female albino Wistar rats. Plos one, 17(7), e0269983.
Nguyen TT, Ketha A, Hieu HV, Tatipamula VB. (2021). In vitro antimycobacterial studies of flavonols from Bauhinia vahlii Wight and Arn. 3 Biotech, 11(3), 128.
Nguyen TT, Nallapaty S, Rao GK, Koneru ST, Annam SS, Tatipamula VB. (2020). Evaluating the in vitro activity of depsidones from Usnea subfloridana Stirton as key enzymes involved in inflammation and gout. Pharmaceutical Sciences, 27(2), 291-296.
Norman J, Madurawe RD, Moore CM, Khan MA, Khairuzzaman A. (2017). A new chapter in pharmaceutical manufacturing: 3D-printed drug products. Advanced Drug Delivery Reviews, 108, 39-50.
Olejnik A, Semba JA, Kulpa A, Danczak-Pazdrowska A, Rybka JD, Gornowicz-Porowska J. (2021). 3D bioprinting in skin related research: recent achievements and application perspectives. ACS Synthetic Biology, 11(1), 26-38.
Ovsianikov A, Chichkov B, Mente P, Monteiro‐Riviere NA, Doraiswamy A, Narayan RJ. (2007). Two photon polymerization of polymer–ceramic hybrid materials for transdermal drug delivery. International Journal of Applied Ceramic Technology, 4(1), 22-29.
Paidi KR, Tatipamula VB, Kolli MK, Annam SS, Pedakotla VR. (2017). Synthesis of imidazo [1, 2-b] pyridazine comprised piperazine, morpholine derivatives as potent antimycobacterial agents with in vivo locomotor activity. Anti-Infective Agents, 15(2), 131-139.
Palo M, Holländer J, Suominen J, Yliruusi J, Sandler N. (2017). 3D printed drug delivery devices: perspectives and technical challenges. Expert Review of Medical Devices, 14(9), 685-696.
Pardeike J, Strohmeier DM, Schrödl N, Voura C, Gruber M, Khinast JG, Zimmer A. (2011). Nanosuspensions as advanced printing ink for accurate dosing of poorly soluble drugs in personalized medicines. International Journal of Pharmaceutics, 420(1), 93-100.
Parhi R. (2021). A review of three-dimensional printing for pharmaceutical applications: Quality control, risk assessment and future perspectives. Journal of Drug Delivery Science and Technology, 64, 102571.
Park BJ, Choi HJ, Moon SJ, Kim SJ, Bajracharya R, Min JY, Han HK. (2019). Pharmaceutical applications of 3D printing technology: current understanding and future perspectives. Journal of Pharmaceutical Investigation, 49, 575-585.
Pere CP, Economidou SN, Lall G, Ziraud C, Boateng JS, Alexander BD, Lamprou DA, Douroumis D. (2018). 3D printed microneedles for insulin skin delivery. International Journal of Pharmaceutics, 544(2), 425-432.
Phan VG, Murugesan M, Huong H, Le TT, Phan TH, Manivasagan P, Mathiyalagan R, Jang ES, Yang DC, Li Y, Thambi T. (2022). Cellulose nanocrystals-incorporated thermosensitive hydrogel for controlled release, 3D printing, and breast cancer treatment applications. ACS Applied Materials & Interfaces, 14(38), 42812-42826.
Placone JK, Engler AJ. (2018). Recent advances in extrusion‐based 3D printing for biomedical applications. Advanced Healthcare Materials, 7(8), 1701161.
Polimati H, Pragada RR, Thuan NH, Tatipamula VB. (2022). Hepatoprotective potential of bioflavonoids. Studies in Natural Products Chemistry, 72, 259-285.
Pradeep PV, Paul L. (2022). Review on novel biomaterials and innovative 3D printing techniques in biomedical applications. Materials Today: Proceedings, 58, 96-103.
Prasad E, Islam MT, Goodwin DJ, Megarry AJ, Halbert GW, Florence AJ, Robertson J. (2019). Development of a hot-melt extrusion (HME) process to produce drug loaded Affinisol™ 15LV filaments for fused filament fabrication (FFF) 3D printing. Additive Manufacturing, 29, 100776.
Prausnitz MR, Langer R. (2008). Transdermal drug delivery. Nature Biotechnology, 26(11), 1261-1268.
Pyteraf J, Pacławski A, Jamróz W, Mendyk A, Paluch M, Jachowicz R. (2022). Application and multi-stage optimization of daylight polymer 3D printing of personalized medicine products. Pharmaceutics, 14(4), 843.
Quanjin M, Rejab MR, Idris MS, Kumar NM, Abdullah MH, Reddy GR. (2020). Recent 3D and 4D intelligent printing technologies: A comparative review and future perspective. Procedia Computer Science, 167, 1210-1219.
Rahimnejad M, Rezvaninejad R, Rezvaninejad R, França R. (2021). Biomaterials in bone and mineralized tissue engineering using 3D printing and bioprinting technologies. Biomedical Physics & Engineering Express, 7(6), 062001.
Rani P, Yadav V, Pandey P, Yadav K. (2023). Recent patent-based review on the role of three-dimensional printing technology in pharmaceutical and biomedical applications. Pharmaceutical Patent Analyst, 12(4), 159-175.
Rao CB, Babu DC, Bharadwaj TV, Srikanth D, Vardhan KS, Raju TV, Bunce RA, Venkateswarlu Y. (2015). Isolation, structural assignment and synthesis of (SE)-2-methyloctyl 3-(4-methoxyphenyl) propenoate from the marine soft coral Sarcophyton ehrenbergi. Natural Product Research, 29(1), 70-76.
Rastogi V, Yadav P. (2012). Transdermal drug delivery system: An overview. Asian Journal of Pharmaceutics, 6(3), 161-170.
Rehman FU, Shah KU, Shah SU, Khan IU, Khan GM, Khan A. (2017). From nanoemulsions to self-nanoemulsions, with recent advances in self-nanoemulsifying drug delivery systems (SNEDDS). Expert Opinion on Drug Delivery, 14(11), 1325-1340.
Repka MA, Bandari S, Kallakunta VR, Vo AQ, McFall H, Pimparade MB, Bhagurkar AM. (2018). Melt extrusion with poorly soluble drugs–An integrated review. International Journal of Pharmaceutics, 535(1-2), 68-85.
Rowe CW, Katstra WE, Palazzolo RD, Giritlioglu B, Teung P, Cima MJ. (2000). Multimechanism oral dosage forms fabricated by three dimensional printing™. Journal of Controlled Release, 66(1), 11-17.
Sadia M, Sośnicka A, Arafat B, Isreb A, Ahmed W, Kelarakis A, Alhnan MA. (2016). Adaptation of pharmaceutical excipients to FDM 3D printing for the fabrication of patient-tailored immediate release tablets. International Journal of Pharmaceutics, 513(1-2), 659-668.
Salawi A. (2022). An insight into preparatory methods and characterization of orodispersible film – A review. Pharmaceuticals, 15(7), 844.
Samiei N. (2020). Recent trends on applications of 3D printing technology on the design and manufacture of pharmaceutical oral formulation: a mini review. Beni-Suef University Journal of Basic and Applied Sciences, 9, 1-2.
Scoutaris N, Alexander MR, Gellert PR, Roberts CJ. (2011). Inkjet printing as a novel medicine formulation technique. Journal of Controlled Release, 156(2), 179-185.
Sen K, Mehta T, Sansare S, Sharifi L, Ma AW, Chaudhuri B. (2021). Pharmaceutical applications of powder-based binder jet 3D printing process–a review. Advanced Drug Delivery Reviews, 177, 113943.
Serrano DR, Kara A, Yuste I, Luciano FC, Ongoren B, Anaya BJ, Molina G, Diez L, Ramirez BI, Ramirez IO, Sánchez-Guirales SA. (2023). 3D printing technologies in personalized medicine, nanomedicines, and biopharmaceuticals. Pharmaceutics, 15(2), 313.
Shabbirahmed AM, Sekar R, Gomez LA, Sekhar MR, Hiruthyaswamy SP, Basavegowda N, Somu P. (2023). Recent developments of silk-based scaffolds for tissue engineering and regenerative medicine applications: a special focus on the advancement of 3D printing. Biomimetics, 8(1), 16.
Shahrubudin N, Koshy P, Alipal J, Kadir MH, Lee TC. (2020). Challenges of 3D printing technology for manufacturing biomedical products: A case study of Malaysian manufacturing firms. Heliyon, 6(4), e03734.
Skoog SA, Goering PL, Narayan RJ. (2014). Stereolithography in tissue engineering. Journal of Materials Science: Materials in Medicine, 25, 845-856.
Sommonte F, Denora N, Lamprou DA. (2023). Combining 3D printing and microfluidic techniques: A powerful synergy for nanomedicine. Pharmaceuticals, 16(1), 69.
Tatipamula VB, Annam SS, Nguyen HT, Polimati H, Yejella RP. (2021). Sekikaic acid modulates pancreatic β-cells in streptozotocin-induced type 2 diabetic rats by inhibiting digestive enzymes. Natural Product Research, 35(23), 5420-5424.
Tatipamula VB, Annam SS. (2022). Antimycobacterial activity of acetone extract and isolated metabolites from folklore medicinal lichen Usnea laevis Nyl. against drug-sensitive and multidrug-resistant tuberculosis strains. Journal of Ethnopharmacology, 282, 114641.
Tatipamula VB, Ketha A, Nallapaty S, Kottana H, Koneru ST. (2021a). Moss Octoblepharum albidum Hedw.: Isolation, characterization, in vitro and in vivo antidiabetic activities. Advances in Traditional Medicine, 21, 351-360.
Tatipamula VB, Ketha A. (2020). Manglicolous lichen Parmotrema tinctorum (Despr. ex Nyl.) Hale: Isolation, characterization and biological evaluation. Indian Journal of Chemistry - Section B, 59(06), 856-861.
Tatipamula VB, Nguyen HT, Kukavica B. (2022). Beneficial effects of liposomal formulations of lichen substances: A review. Current Drug Delivery, 19(3), 252-259.
Tatipamula VB, Polimati H, Gopaiah KV, Babu AK, Vantaku S, Rao PR, Killari KN. (2020). Bioactive metabolites from manglicolous lichen Ramalina leiodea (Nyl.) Nyl. Indian Journal of Pharmaceutical Sciences, 82(2), 379-84.
Tatipamula VB. (2022). Seaweed Chara baltica: Isolation, characterization and in vivo antidiabetic study. Brazilian Journal of Pharmaceutical Sciences, 58, e19323.
Thuan NH, Tatipamula VB, Canh NX, Giang VN. (2022). Recent advances in microbial co-culture for production of value-added compounds. 3 Biotech, 12(5), 115.
Thuan NH, Tatipamula VB, Viet TT, Tien NQ, Loc NH. (2022a). Bioproduction of eriodictyol by Escherichia coli engineered co-culture. World Journal of Microbiology and Biotechnology, 38(7), 112.
Tian Y, Chen C, Xu X, Wang J, Hou X, Li K, Lu X, Shi H, Lee ES, Jiang HB. (2021). A review of 3D printing in dentistry: Technologies, affecting factors, and applications. Scanning, 2021(1), 9950131.
Tran V, Wen X. (2014). Rapid prototyping technologies for tissue regeneration. Rapid Prototyping of Biomaterials, 97-155.
Trenfield SJ, Awad A, Goyanes A, Gaisford S, Basit AW. (2018). 3D printing pharmaceuticals: drug development to frontline care. Trends in Pharmacological Sciences, 39(5), 440-451.
Trenfield SJ, Awad A, Madla CM, Hatton GB, Firth J, Goyanes A, Gaisford S, Basit AW. (2019). Shaping the future: recent advances of 3D printing in drug delivery and healthcare. Expert Opinion on Drug Delivery, 16(10), 1081-1094.
Uddin MJ, Scoutaris N, Klepetsanis P, Chowdhry B, Prausnitz MR, Douroumis D. (2015). Inkjet printing of transdermal microneedles for the delivery of anticancer agents. International Journal of Pharmaceutics, 494(2), 593-602.
Urbán-Morlán Z, Serrano-Mora LE, Martínez-Acevedo L, Leyva-Gómez G, Mendoza-Muñoz N, Quintanar-Guerrero D. (2021). New developments in intrauterine drug delivery systems and devices. In Drug Delivery Devices and Therapeutic Systems, Edited by Eric Chappel, Academic Press. p. 601-622.
Vakili H, Nyman JO, Genina N, Preis M, Sandler N. (2016). Application of a colorimetric technique in quality control for printed pediatric orodispersible drug delivery systems containing propranolol hydrochloride. International Journal of Pharmaceutics, 511(1), 606-618.
Viidik L, Vesala J, Laitinen R, Korhonen O, Ketolainen J, Aruväli J, Kirsimäe K, Kogermann K, Heinämäki J, Laidmäe I, Ervasti T. (2021). Preparation and characterization of hot-melt extruded polycaprolactone-based filaments intended for 3D-printing of tablets. European Journal of Pharmaceutical Sciences, 158, 105619.
Vyshnavi J, Ramesh Y, Venugopalaiah P, Chandra YP. (2023). 3D printing technology in pharmaceutical science. International Journal of Pharmacometrics and Integrated Biosciences, 8(2), 5-17.
Wang CC, Tejwani MR, Roach WJ, Kay JL, Yoo J, Surprenant HL, Monkhouse DC, Pryor TJ. (2003). Development of near zero-order release dosage forms using threedimensional printing (3-DP™) technology. Drug Development and Industrial Pharmacy, 32(3), 367-376.
Wang J, Goyanes A, Gaisford S, Basit AW. (2016). Stereolithographic (SLA) 3D printing of oral modified-release dosage forms. International Journal of Pharmaceutics, 503(1-2), 207-212.
Wang J, Zhang Y, Aghda NH, Pillai AR, Thakkar R, Nokhodchi A, Maniruzzaman M. (2021). Emerging 3D printing technologies for drug delivery devices: Current status and future perspective. Advanced Drug Delivery Reviews, 174, 294-316.
Wang JC, Zheng H, Chang MW, Ahmad Z, Li JS. (2017). Preparation of active 3D film patches via aligned fiberelectrohydrodynamic (EHD) printing. Scientific Reports, 7(1), 43924.
Warsi MH, Yusuf M, Al Robaian M, Khan M, Muheem A, Khan S. (2018). 3D printing methods for pharmaceutical manufacturing: opportunity and challenges. Current Pharmaceutical Design, 24(42), 4949-4956.
Wong KC. (2016). 3D-printed patient-specific applications in orthopedics. Orthopedic Research and Reviews, 57-66.
Wu W, Zheng Q, Guo X, Sun J, Liu Y. (2009). A programmed release multi-drug implant fabricated by three-dimensional printing technology for bone tuberculosis therapy. Biomedical Materials, 4(6), 065005.
Xu X, Seijo-Rabina A, Awad A, Rial C, Gaisford S, Basit AW, Goyanes A. (2022). Smartphone-enabled 3D printing of medicines. International Journal of Pharmaceutics, 609, 121199.
Yang Y, Xu Y, Wei S, Shan W. (2021). Oral preparations with tunable dissolution behavior based on selective laser sintering technique. International Journal of Pharmaceutics, 593, 120127.
Yi HG, Choi YJ, Kang KS, Hong JM, Pati RG, Park MN, Shim IK, Lee CM, Kim SC, Cho DW. (2016). A 3D-printed local drug delivery patch for pancreatic cancer growth suppression. Journal of Controlled Release, 238, 231-241.
Yu DG, Branford-White C, Ma ZH, Zhu LM, Li XY, Yang XL. (2009). Novel drug delivery devices for providing linear release profiles fabricated by 3DP. International Journal of Pharmaceutics, 370(1-2), 160-166.
Zhang J, Feng X, Patil H, Tiwari RV, Repka MA. (2017). Coupling 3D printing with hotmelt extrusion to produce controlled-release tablets. International Journal of Pharmaceutics, 519(1-2), 186-197.
Zhang M, Zhang C, Li Z, Fu X, Huang S. (2023). Advances in 3D skin bioprinting for wound healing and disease modeling. Regenerative Biomaterials, 10, rbac105.
Zhang Y, Zhou D, Chen J, Zhang X, Li X, Zhao W, Xu T. (2019). Biomaterials based on marine resources for 3D bioprinting applications. Marine Drugs, 17(10), 555.
Zhu W, Webster TJ, Zhang LG. (2018). How can 3D printing be a powerful tool in nanomedicine?. Nanomedicine, 13(3), 251-253.
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