Isolation of Alkaloids from Artabotrys suaveolens and Their Cytotoxic Activity

Abstract

A phytochemical investigation on the stem bark of Artabotrys suaveolens has led to the isolation of an azaanthraquinone, cleistopholine (1) a dioxoaporphine alkaloid, artabotrine (2) and a benzylisoquinoline alkaloid, reticuline (3) The compounds were isolated using various chromatographic methods. The structures were mainly determined by spectroscopic methods such as 1H and 13C NMR, mass spectrometry and also by comparison with previous data. The compounds (1-3) have been isolated from others Atrabotrys species but here we are reporting for the first time from Artabotrys suaveolens. Meanwhile, artabotrine (2) showed a moderate cytotoxicity against human cancer cell lines, HL60, HCT116, RPMI8226 and MCF 7.