Isoquinoline Alkaloids and Antimalarial Properties of Popowia Perakensis Extract

  • Saripah Salbiah Syed Abd. Aziz
  • Mat Ropi Mukhtar
  • A. Hamid A. Hadi
  • Noor Rain Abdullah
  • Khalijah Awang
Keywords: Isoquinoline, Popowia perakensis, alkaloid, antimalarial activity, Plasmodium falciparum

Abstract

Further investigation on the alkaloidal composition on the bark of the Malaysian Popowia perakensis King collected from Mersing, Johore afforded four isoquinoline alkaloids, i.e atherospermidine 1, (-)-anonaine 2, (-)-norstephalagine 3 and (-)-asimilobine 4. These compounds were elucidated and identified via spectroscopic methods mainly 1H-NMR, 13C-NMR, IR, UV, GCMS and by comparison with literature data. The crude alkaloid extract was screened for antimalarial activity towards Plasmodium falciparum in vitro using the lactate dehyrogenase (LDH) assay to give IC50 value of 6.85 μg/ml. 

 

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Author Biographies

Saripah Salbiah Syed Abd. Aziz

Department of Chemistry, Faculty of Science, Universiti Pendidikan Sultan Idris, 35900 Tanjong Malim, Perak, Malaysia

Mat Ropi Mukhtar

Department of Chemistry, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia

A. Hamid A. Hadi

Department of Chemistry, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia

Noor Rain Abdullah

Herbal Medicine Research Centre, Institute for Medical Research, 50588 Jalan Pahang, Kuala Lumpur, Malaysia

Khalijah Awang

Department of Chemistry, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia.

Published
2009-12-09
How to Cite
Syed Abd. Aziz, S. S., Mukhtar, M. R., A. Hadi, A. H., Abdullah, N. R., & Awang, K. (2009). Isoquinoline Alkaloids and Antimalarial Properties of Popowia Perakensis Extract. Journal of Science and Mathematics Letters, 1(2), 80-86. Retrieved from https://ejournal.upsi.edu.my/index.php/JSML/article/view/382