Antibacterial Activity of Phytochemicals from Garcinia parvifolia Miq. and Garcinia hombroniana Pierre

Abstract

Phytochemical studies on the stem bark of Garcinia parvifolia and pericarp of Garcinia hombroniana have been investigated. The crude extracts were purified using chromatographic techniques to obtain pure compounds named as rubraxanthone (1), parvixanthone G (2) cowanin (3), garcihombronane B (4), garcihombronane C (5) and stigmasterol (6). The structures of all compounds were characterized by spectroscopic methods. The extracts and phytochemicals were tested for their antibacterial activity using disc diffusion method, minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC). Acetone extract of the pericarp of G. hombroniana showed the most significant antibacterial activity with MIC and MBC values of 225 µg/mL, meanwhile, compound (3) exhibited the most significant antibacterial activity compared to other xanthones with MBC value of 225 µg/mL.

Clusiaceae; Garcinia parvifolia; Garcinia hombroniana; antibacterial