Acetylcholinesterase Activity of Crude Extracts and Flavonoids from Artocarpus anisophyllus Miq. and Artocarpus lowii King

Authors

  • Siti Awanis Abdullah Department of Chemistry, Faculty of Science, Universiti Teknologi Malaysia, 81310 UTM Johor Bahru, Johor, MALAYSIA
  • Siti Mariam Abdul Lathiff Department of Chemistry, Faculty of Science, Universiti Teknologi Malaysia, 81310 UTM Johor Bahru, Johor, MALAYSIA
  • Shajarahtunnur Jamil Department of Chemistry, Faculty of Science, Universiti Teknologi Malaysia, 81310 UTM Johor Bahru, Johor, MALAYSIA

DOI:

https://doi.org/10.37134/jsml.vol10.2.7.2022

Keywords:

Acetylcholinesterase, Plant Extracts, Flavonoids, Artocarpus, TLC

Abstract

A flavonoids-rich extract and seven flavonoids from the leaves and heartwoods of A. anisophyllus Miq. and  A. lowii King were investigated for their inhibitory effects against acetylcholinesterase enzyme. The flavonoids were fully characterized spectroscopically as artocarpin (1), isobavachalcone (2), pyranocycloartobiloxanthone A (3), 5,7-dihydroxy-4'-methoxy-6-prenylflavanone (4), 5-hydroxy-7,8-(2,2-dimethylchromano)-4'-methoxy-flavanone (5) 4',5-dihydroxy-6,7-(2,2-dimethylpyrano)-2'-methoxy-8-γ,γ-dimethylallylflavone (6) and 2',4'-dihydroxy-3,4-(2",2"-dimethylchromeno)-3'-prenyldihydrochalcone (7). Acetylcholinesterase inhibitory activity of the samples was determined using TLC plate with bioactivity staining based on the Ellman’s method. Pyranocycloartobiloxanthone A (3) exhibited an excellent inhibitory activity with detection limit at 7.81 µg/mL.

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References

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Published

2022-10-21

How to Cite

Abdullah, S. A., Abdul Lathiff, S. M., & Jamil, S. (2022). Acetylcholinesterase Activity of Crude Extracts and Flavonoids from Artocarpus anisophyllus Miq. and Artocarpus lowii King. Journal of Science and Mathematics Letters, 10(2), 62–66. https://doi.org/10.37134/jsml.vol10.2.7.2022